Sqwod Evidence

Supplements A to Z

The 12 supplements clients ask about most, graded by the research. Each row sums up a sourced playbook: what works, for whom, and what to skip.

Updated · 12 supplements · 10 playbooks

All supplements with verdict and evidence
SupplementVerdictEvidence
Ashwagandha Conditional yes Moderate (stress, sleep)
BCAAs Skip Strong: no benefit over enough protein
Beta-alanine Conditional yes Strong for the window, small effect
Caffeine Default yes Strong
Creatine monohydrate Default yes Strong
Fish oil (omega-3) Conditional yes Moderate for pain; none for muscle
Magnesium Conditional yes Moderate when intake is low
Pre-workouts and fat burners Skip Strong: highest contamination risk
Protein powder Default yes Strong
Research peptides Avoid Preclinical (BPC-157, TB-500)
Testosterone boosters Skip Strong: claims not supported
Vitamin D Conditional yes Moderate for people who are low

Ashwagandha

Conditional yes Evidence: Moderate (stress, sleep)

Small, real effects on stress and sleep. Screen first: rare liver injury is documented, and pregnancy is a clear no.

Ashwagandha playbook →

BCAAs branched-chain amino acids

Skip Evidence: Strong: no benefit over enough protein

Only 3 of the 9 essential amino acids. Some relief from soreness, but no extra gains once daily protein is covered.

BCAAs playbook →

Beta-alanine

Conditional yes Evidence: Strong for the window, small effect

Helps only in hard efforts of about 30 seconds to 10 minutes. No effect on body composition. The tingle is a side effect, not proof it works.

Beta-alanine playbook →

Caffeine

Default yes Evidence: Strong

About 2 to 4% faster endurance time trials at 3 to 6 mg/kg, roughly 60 minutes before. A tool for the session: it costs sleep if taken late.

Caffeine playbook →

Fish oil (omega-3) EPA, DHA

Conditional yes Evidence: Moderate for pain; none for muscle

Not a muscle builder. Moderate help for chronic pain, but not for osteoarthritis. Heart-rhythm risk rises above 1 g a day, so more is not better.

Fish oil (omega-3) playbook →

Magnesium

Conditional yes Evidence: Moderate when intake is low

Worth it when intake is low, which is common. The sleep effect is modest and uncertain, and it does not help common night cramps. Choose citrate or glycinate over oxide.

Magnesium playbook →

Research peptides BPC-157, TB-500, MK-677

Avoid Evidence: Preclinical (BPC-157, TB-500)

Almost all animal data. Unapproved, unregulated and banned in tested sport. MK-677 added mass but no strength, and raised blood sugar.

Research peptides playbook →

Vitamin D

Conditional yes Evidence: Moderate for people who are low

A correction supplement, not a performance one. Helps people who are low, which is common in European winters. No effect on fractures, and high doses carry risk.

Vitamin D playbook →
Before any effect: is it clean? In an analysis of 200 sports supplements (Sport Integrity Australia, 2022), 35% contained substances on the WADA prohibited list. Recommend only products with third-party batch certification. The full supplement triage →

Common questions

Which supplements actually work for strength training?

Three earn a default yes for a general training population: creatine monohydrate, caffeine for specific sessions, and protein powder only when food leaves a gap. Beta-alanine helps only in hard efforts of about 30 seconds to 10 minutes.

Which supplements can my clients skip?

BCAAs when daily protein is already adequate, testosterone boosters, and multi-ingredient pre-workouts and fat burners. These claims have been studied and do not hold up.

How do I know a supplement is clean?

Buy only products with third-party batch certification. In a 2022 Sport Integrity Australia analysis of 200 sports supplements, 35% contained substances on the WADA prohibited list, and most of those were not listed on the label.

Which product? The evidence tells you what works. Sqwod Verified tells you which product, with the testing check. Best supplements →